Introduction of soft capsule gelatin

1. It should not be opened when taking gelatin capsules
Some drugs have a stimulating effect on the esophagus and gastric mucosa, and may even cause burns. These drugs are packed in capsules to protect the esophagus and respiratory tract from damage. Some capsules are enteric-coated capsules. The shell of the gelatin capsule can transport the medicine all the way into the intestine, so that the ingredients of the drug can avoid the decomposition of stomach acid and reach the intestine safely to be effectively absorbed. In addition, the shell of the gelatin capsule also stabilizes the efficacy of the medicine. . If the capsule shell is removed while taking the gelatin capsule, it may reduce the efficacy of the medicine and increase the toxic side effects.
2. It is not advisable to swallow directly when taking gelatin capsules
When taking a gelatin capsule, if it is swallowed dry and hard, it may cause the gelatin of the capsule to adhere to the esophagus after absorbing water, and the local drug concentration will be too high, which will harm the esophagus and cause mucosal damage and even ulcers.
3. When taking gelatin capsules, it is not advisable to take it with hot water
The shell of gelatin capsule will absorb water and become soft in cold water, but will melt and dissolve quickly in hot water. If the medicine is taken with hot water, the shell of the capsule is easily damaged, and the medicine inside will be released in advance, which affects the effectiveness and safety. Therefore, it is more appropriate to take the gelatin capsule medicine with cold water (not too ice) or warm water.

Gelatin, a colorless to light yellow solid, in the form of powder, flakes or lumps. It is shiny, odorless, and tasteless. The relative molecular mass is about 50,000 to 100,000. The relative density is 1.3～1.4. It is insoluble in water, but when immersed in water, it can absorb 5-10 times of water to swell and soften. If heated, it will dissolve into a colloid, and it will become a gel when cooled to below 35-40°C; if the aqueous solution is boiled for a long time, The properties change due to decomposition, and no gel is formed after cooling. It is insoluble in ethanol and chloroform, but soluble in hot water, glycerin, propylene glycol, acetic acid, salicylic acid, phthalic acid, urea, thiourea, thiocyanate and potassium bromide. This product does not solidify when the concentration is below 5%, and usually forms a gel with a 10%-15% solution. The gelation temperature varies with concentration, coexisting salts and pH value. Viscosity and gel strength vary with the relative molecular mass distribution, and are also affected by pH, temperature and electrolyte. If the solution of this product encounters formaldehyde, it will become an irreversible gel that is insoluble in water. This product is easy to absorb moisture, due to bacteria, please pay attention to it when storing. When hydrolyzed, various amino acids can be obtained

(1) Liquid oily substances can be directly enclosed in capsules, without the use of additives such as adsorption and inclusion, and the content of oily substances in soft capsules is as high as 60%-85% (weight), while the content of inclusions is generally below 50% .
(2) If thick gelatin is used to make the film, it can be completely hermetically sealed, the capsule has high strength and film covering properties, and the contents can be kept stable for a long time. According to measurements, the gelatin film has more than 30 times the oxygen shielding properties of polyethylene film. It is very stable to oxygen in the air and can prevent air oxidation and moisture absorption.
(3) After ingestion, the contents are released quickly, the utilization rate in the body is high, and the absorption rate is high.
(4) The content has good uniformity and the content deviation is very low.
(5) It can cover the peculiar smell and smell of some contents, especially for some functional health foods and pharmaceutical applications. Because it is different from general food, it has many peculiar smells and smelly ingredients.